Regenerative Medicine Advanced Therapy Designation (RMAT)

As described in Section 3033 of the 21st Century Cures Act, a drug is eligible for RMAT designation if:

• The drug is a regenerative medicine therapy, which is defined as a cell therapy, therapeutic tissue engineering product, human cell and tissue product, or any combination product using such therapies or products, except for those regulated solely under Section 361 of the Public Health Service Act and part 1271 of Title 21, Code of Federal Regulations;
• The drug is intended to treat, modify, reverse, or cure a serious or life-threatening disease or condition; and
• Preliminary clinical evidence indicates that the drug has the potential to address unmet medical needs for such disease or condition

The request for RMAT designation must be made either concurrently with submission of an Investigational New Drug application (IND) or as an amendment to an existing IND.