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Marie-Agnès Cassar, PhD
Senior Director, Nonclinical Development and Clinical Pharmacology
As a Senior Director in the Nonclinical and Clinical Team at VCLS, Marie-Agnès is responsible for the management of nonclinical projects (pharmacology, pharmacokinetics, toxicology), the provision of scientific, technical and regulatory advice to operational areas and clients, and the preparation and review of nonclinical regulatory documentation. Her involvement in pharmacokinetics and specifically Drug-Drug Interaction has earned her considerable assets to provide support in Clinical Pharmacology.
Since joining VCLS, she has worked on a significant number of major life-sciences projects, including gap analyses, project development plans, nonclinical and clinical regulatory documentation (briefing packages, IBs, INDs, IMPDs, DSURs etc..), CTD Modules (2.4, 2.6, 2.7) and agency meetings. She has worked with new chemical entities, well established products, combination products and biologics across a range of therapeutic areas including oncology, anti-infectious, CNS disorders, cardiovascular disorders, ophthalmology and dermatology.
Marie-Agnès brings to the role more than 25 years of experience, having worked as a toxicologist and nonclinical manager in both the pharmaceutical industry and in a contract research organisation. Prior to joining VCLS, Marie-Agnès worked at Debiopharm, where she developed an expertise in the fields of oncology and anti-infective therapeutics (small molecules and biologics). She also worked for 11 years at Galderma R&D as a nonclinical Manager. During this time Marie-Agnès developed substantial experience in the development of dermatology products (small molecules), cosmetics, OTC products and medical devices. Marie-Agnès started her career working for MDS Pharma Services as a Study Director in general toxicology.
Marie-Agnès completed a Ph.D. in Pharmacology (« Sciences du Medicament ») at the University Henri-Poincaré Nancy in 1999, followed by two years conducting post-doctoral research and teaching. She was awarded European Registered Toxicologist status in 2008.
Marie-Agnès is based in our Lausanne office in Switzerland.